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CDC Draft Clinical Practice Guideline for Prescribing Opioids

February 14, 2022 3:14 PM | Judy Pfeiffer (Administrator)

The CDC draft Clinical Practice Guideline for Prescribing Opioids (update to the 2016 Guideline for Prescribing Opioids for Chronic Pain) has posted in the Federal Register and the 60-day public comment period begins today. Public comment provides valuable insight from the populations that we serve. Please note that the 60-day public comment period will end on April 11, 2022. 

CDC is committed to supporting safe and effective pain care options for patients. CDC’s National Center for Injury Prevention and Control (NCIPC) is in the process of updating the 2016 CDC Guideline for Prescribing Opioids for Chronic Pain. Both healthcare professionals and members of the public who experience acute or chronic pain have expressed interest in understanding the recommendations outlined in the draft updated Guideline, and CDC highly values public and partner engagement and feedback in this process.

<Visit the Federal Register to provide your comments on the draft Guideline update> 

Please see our webpage detailing the process of updating the Guideline. Encourage people you know who have direct experience with the role of opioids in pain care and the importance of the patient-clinician relationship to visit the Federal Register, review the draft update to the Guideline, and add their perspectives to the Federal Register Notice.  

Submitting a Comment

See below for instructions to submit a comment during the public comment period. More detailed instructions can also be found on the Federal Register Notice (FRN) webpage and in the FRN for this document.  

To locate the FRN and view the draft of the updated Guideline, you can either:   

To submit a comment to CDC, please view the methods outlined in the FRN under the "Addresses" heading and select which option you prefer:

  • Electronic comments via the website 
  • Go to and search for "CDC Guideline for Prescribing Opioids"
  • A comment button on the top left of the page will allow you to submit your comments via a webpage with step-by-step instructions
  • Mail
  • Directions for how to submit a comment through the mail are provided in the "Addresses" section of the FRN on

To ask a question, click on the “For Further Information Contact” heading in the FRN for the agency official contact information. 

General information about the process to provide a public comment can be found at the following links:  


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